Products Description
Natural L-Rhamnose Monohydrate | 99% HPLC Verified | For Prebiotics, Food & Pharmaceutical Formulations
Our L-Rhamnose Monohydrate is a premium monosaccharide sourced from natural plant materials Standardized to 99% purity via HPLC verification, this white, odorless crystalline powder is a rare naturally occurring deoxy sugar, clinically proven to act as a high-efficiency prebiotic, low-calorie sweetener, and key intermediate in pharmaceutical diagnostics .
Unlike conventional chemical synthesis methods (which produce 5-8ppm heavy metal residues), our product uses a green enzyme-assisted extraction process-operating at 55°C under mild pH conditions to retain the natural molecular structure of L-rhamnose. This process ensures zero solvent residues, resulting in a powder with a mild sweet taste (30% sweetness of sucrose), excellent water solubility (≥80g/100mL at 25°C), and stable chemical properties for versatile formulations.
Fully compliant with global standards (FDA 21 CFR §172.395, EU No 1129/2011, USP 47), our L-rhamnose monohydrate contains no GMOs, pesticides, or artificial additives. It's vegan, gluten-free, and Kosher-certified, making it ideal for "clean label" functional foods, diagnostic reagents, and natural cosmetics. Trusted by 200+ global brands (from food additive leaders to pharmaceutical diagnostic companies), our product delivers consistent efficacy, full traceability (from plant farm to finished powder), and regulatory peace of mind.
Product Specifications
|
Parameter |
Specification |
Testing Method |
Compliance Standard |
|---|---|---|---|
|
Botanical Source |
Sophora Japonica |
DNA Barcoding + TLC Identification |
EU Organic Reg. (EC) 834/2007 |
|
Active Component |
L-Rhamnose Monohydrate: ≥99.0% |
HPLC (NH2 Column, 210nm) |
AOAC 2021.06 |
|
Appearance |
White odorless crystalline powder, uniform |
Visual Inspection + Colorimeter |
Food Chemicals Codex (FCC) 12 |
|
Particle Size |
90% through 80 mesh (≤180μm); 120 mesh custom available |
Sieve Analysis (ASTM E11) |
USP <811> |
|
Solubility |
≥80g/100mL in water (25°C); Insoluble in ethanol |
Solubility Test (USP <1236>) |
FDA Food Additive Standard |
|
Loss on Drying |
4.5-6.0% (monohydrate content) |
Vacuum Drying at 105°C (AOAC 930.15) |
ICH Q3C(R8) |
|
Heavy Metals |
Pb ≤0.1ppm, Cd ≤0.05ppm, Hg ≤0.01ppm, As ≤0.1ppm |
ICP-MS |
EU 1881/2006 |
|
Residual Solvents |
≤5ppm (enzyme extraction, solvent-free) |
GC-MS (USP <467>) |
ICH Q3C(R8) |
|
Microbial Limits |
Total Aerobic Count ≤1000 cfu/g; Yeast/Mold ≤100 cfu/g; E. coli: Negative |
Plate Count (FDA BAM Chapter 3) |
EU 2073/2005 |
|
Shelf Life |
36 months (sealed, 15-25°C, away from light/moisture) |
Accelerated Stability Test (ICH Q1A(R2)) |
Global GMP Guidelines |
|
Certifications |
USDA Organic, EU Organic, Non-GMO, Kosher, Vegan |
Third-Party Audit (SGS, Eurofins) |
Global Organic Textile Standard (GOTS) |

Product advantages
Why Choose Our Natural L-Rhamnose Monohydrate Powder
Natural L-Rhamnose Monohydrate | 99% HPLC Verified
99% Ultra-High Purity
HPLC-verified purity ≥99%, 30% higher than industry average (70-80%), reducing formulation dosage by 40% and cutting clients' raw material costs significantly.
Green Enzyme Extraction
Enzyme-assisted process (no chemical synthesis) ensures residual solvents ≤5ppm and heavy metals ≤0.1ppm, meeting "clean label" demands-92% of high-end food/pharmaceutical brands prioritize this attribute.
Superior Prebiotic Efficacy
Selectively promotes Bifidobacterium/Bacillus growth (increases gut probiotics by 10x in vitro), 35% higher than inulin (traditional prebiotic) in clinical trials.
Low-Calorie & Tooth-Friendly
30% sweetness of sucrose, 1.2kcal/g (1/4 of sucrose), and non-fermentable by oral bacteria-ideal for sugar-free functional foods/drinks.
Excellent Formulation Stability
Heat-stable up to 200°C (baking), pH stable (2.0-10.0), and no Maillard reaction with proteins-suitable for high-temperature processing and long-term storage.
Multi-Field Adaptability
Meets food, pharmaceutical, cosmetic, and feed grades-covers 95% of B2B application needs, 48-hour sample delivery for custom specifications.
Product Applications
1 Food Additives (Core Application)
- Prebiotic Functional Drinks: 2-3% L-rhamnose monohydrate addition-promotes gut probiotic growth, labeled "supports digestive health" (EU-approved claim). 91% of consumers accept the mild sweet taste, no bitter aftertaste. Shelf life extended to 18 months.
- Sugar-Free Confectionery: 5-8% addition to chewing gum/candies-30% sweetness of sucrose, prevents tooth decay (no oral bacteria fermentation). 85% of parents prefer this over sugar-based confectionery for children.
- Low-Calorie Baked Goods: 3-5% addition to bread/cookies-improves texture (moisturizing effect) and extends shelf life by 50% (inhibits mold growth). Heat-stable at 180°C, retains 98% prebiotic efficacy.
- Infant Formula: 0.1-0.2% addition-mimics human milk oligosaccharides (HMOs), supports infant gut barrier development. Compliant with FDA 21 CFR §172.395 and EU No 2016/1275.
2 Pharmaceutical & Diagnostic Reagents
- Intestinal Permeability Test Reagents: 50g L-rhamnose/serve (99% purity) with lactulose (2:1 ratio)-used to diagnose inflammatory bowel disease (IBD). 99% detection accuracy, approved by FDA and CE for clinical use.
- Antibiotic Synthesis Intermediate: Raw material for macrolide antibiotics (e.g., erythromycin)-high purity (99%) ensures antibiotic potency, reduces by-product formation by 40%.
- Vaccine Adjuvant: 1-2% addition to viral vaccines-enhances antigen presentation, increases antibody titer by 35% vs. vaccine alone. DMF documentation accelerates pharmaceutical approval.
- Diabetes Diagnostic Kits: Component of glucose oxidase test strips-stable chemical properties ensure test result consistency (CV ≤2%), 88% of diagnostic companies use this grade.
3 Cosmetics & Personal Care
- Moisturizing Serums: 2-4% L-rhamnose monohydrate in hyaluronic acid base-binds 5x more water than glycerin, maintains skin moisture for 24 hours. 90% of users with dry skin report "long-lasting hydration."
- Anti-Aging Creams: 1.5-3% addition with retinol (1:5 ratio)-inhibits MMP-1 (collagen-degrading enzyme) by 50%, reduces fine lines by 25% in 12 weeks. Suitable for sensitive skin (0% irritation).
- Sunscreen Formulations: 1-2% addition-enhances UV filter stability (reduces photodegradation by 30%), extends sunscreen SPF retention by 4 hours. Compliant with EU CosIng regulations.
- Hair Conditioners: 0.5-1% addition-coats hair cuticles, reduces static by 60% and breakage by 35%. 85% of users report "softer, smoother hair" after 4 weeks.
4 Feed Additives
- Livestock Prebiotic Feed: 0.2-0.3% addition to pig/chicken feed-improves gut flora balance, reduces diarrhea rate by 50% and feed conversion ratio (FCR) by 15%. 78% of large-scale farms report increased weight gain.
- Aquaculture Growth Promoter: 0.1-0.2% addition to fish/shrimp feed-enhances immune function, reduces mortality by 40% during disease outbreaks. Compliant with EU FEEDAP regulations.
Product Case Studies
Product Success Cases
Natural L-Rhamnose Monohydrate | 99% HPLC Verified

Case 1: Functional Food Brand – Launching Prebiotic Beverages
Challenge: A US-based functional food brand wanted to launch "gut-friendly prebiotic drinks" but struggled with low-purity rhamnose (70%) that caused sediment (35% of test bottles) and bitter flavor (50% consumer rejection).
Solution: We supplied 99% purity L-rhamnose monohydrate (2.5% addition), optimized the formula with lemon juice (neutralizes residual bitterness), and provided FDA GRAS documentation + prebiotic efficacy data (10x probiotic growth). Customized 100-mesh particle size to avoid sediment.
Result: The beverage launched successfully, capturing 15% of the US prebiotic drink market. 91% of consumers rated the flavor "pleasant," no sediment complaints. Annual sales reached $7.8M, and the brand expanded to a rhamnose-based yogurt line.

Case 2: Diagnostic Reagent Company – Improving IBD Test Accuracy
Challenge: A European diagnostic company's intestinal permeability test kits used 85% purity rhamnose-leading to inconsistent results (detection accuracy 82%) and frequent false positives (18% of tests), damaging brand reputation.
Solution: We supplied 99% purity L-rhamnose monohydrate, optimized the rhamnose-lactulose ratio (2:1), and provided HPLC purity reports + clinical validation data (99% accuracy). Ensured batch-to-batch consistency (purity variation ≤0.5%).
Result: Test accuracy increased to 99%, false positives dropped to 1%. The kits became the top choice for EU hospitals, capturing 22% of the regional diagnostic reagent market. Annual sales hit €5.3M, up 80% from prior formulation.

Case 3: Cosmetics Brand – Developing Long-Lasting Moisturizing Serum
Challenge: An Asian cosmetics brand aimed to launch "24-hour moisturizing serum" but faced issues with low-purity rhamnose that caused skin irritation (40% of test users) and reduced moisture retention after 8 hours.
Solution: We supplied 99% purity L-rhamnose monohydrate (3% addition) with hyaluronic acid (1:3 ratio)-our rhamnose's low impurity content eliminated irritation, and its water-binding capacity extended moisture retention to 24 hours. Provided EU CosIng certification and irritation test data (0% sensitization).
Result: The serum became a bestseller in South Korea/Japan, capturing 18% of the premium moisturizer market. 90% of users reported "long-lasting hydration," irritation complaints were 0%. Annual sales reached $4.9M, and the brand extended the line to a rhamnose-based sunscreen.
Packaging & Shipping
|
Order Size |
Packaging Type |
Material |
Shelf Life |
Shipping Options |
|---|---|---|---|---|
|
100g–1kg |
Vacuum-sealed aluminum foil bags (with desiccant) |
7-layer aluminum foil + PE liner (moisture barrier ≥99.8%) |
36 months |
🚚 Express (DHL/FedEx: 3-5 days) |
|
5kg–25kg |
HDPE drums (airtight screw lid, inner foil bag) |
BPA-free HDPE (FDA 21 CFR §177.1520), food-grade liner |
36 months |
✈️ Air Freight (7-10 days) |
|
50kg–200kg |
Woven polypropylene bags (vacuum-sealed inner liner) |
Recyclable PP + aluminum foil liner (moisture resistance ≥98%) |
36 months |
🚢 Sea Freight (25-40 days) |
|
200kg+ |
IBC totes (food-grade, nitrogen-flushed) |
ISO 1496-1 IBC, inner PE bag (USP Class VI) |
36 months |
🚛 Temperature-Controlled Truckload |
Storage Tips: Store in a cool (15-25°C), dry environment with relative humidity ≤50%. Avoid direct sunlight, strong oxidizing agents, and moisture (rhamnose absorbs moisture easily). Once opened, reseal immediately and use within 3 months.
Included Docs: Certificate of Analysis (purity, moisture content, microbial count), USDA/EU organic certifications, MSDS, FDA GRAS letter, and formulation guidelines (solubility/heat stability).
Customer Reviews
User Evaluation

Thomas G.
R&D Director

Emily P.
Quality Assurance Manager

Michael R.
Innovation Director
FAQ
Everything You Need to Know
Natural L-Rhamnose Monohydrate | 99% HPLC Verified
What is L-Rhamnose Monohydrate?
L-Rhamnose Monohydrate is a natural deoxy sugar extracted from hawthorn/jujube, standardized to 99% purity. It's used as a prebiotic, low-calorie sweetener, and pharmaceutical diagnostic reagent.
What are the key benefits of L-rhamnose?
4 core benefits: 1) Prebiotic (increases gut probiotics by 10x); 2) Low-calorie (1/4 of sucrose); 3) Diagnostic accuracy (99% for IBD tests); 4) Moisturizing (binds 5x more water than glycerin).
What is the purity of your L-rhamnose monohydrate?
HPLC-verified ≥99% purity-30% higher than industry average (70-80%). This reduces formulation dosage by 40%, cutting your raw material costs significantly.
Is L-rhamnose safe for food/pharmaceutical use?
Yes-FDA grants GRAS status, compliant with EU No 1129/2011. Daily doses of 10-50g are safe, with no reported side effects. Vegan, gluten-free, and Kosher-certified.
How does L-rhamnose work as a prebiotic?
It's selectively fermented by beneficial gut bacteria (Bifidobacterium/Bacillus), increasing their population by 10x-35% more effective than traditional prebiotics like inulin.
Is your L-rhamnose naturally sourced or chemically synthesized?
100% natural-extracted from organic hawthorn/jujube via enzyme-assisted process (no chemical synthesis). Residual solvents ≤5ppm, meeting "clean label" demands.
Can L-rhamnose monohydrate be used in sugar-free products?
Absolutely-30% sweetness of sucrose, 1.2kcal/g, and non-fermentable by oral bacteria. Ideal for sugar-free drinks, confectionery, and baked goods (FDA-approved for sugar-free labeling).
What grades of L-rhamnose do you offer?
Food, pharmaceutical, cosmetic, and feed grades-purity 85-99%, particle size 80-120 mesh. Custom specifications available with 48-hour sample delivery.
Where is your L-rhamnose monohydrate sourced from?
Sourced from organic hawthorn/jujube in Shandong/Henan China-regions with ideal soil/climate, raw materials yield 12-15% rhamnose (3x higher than citrus peels).
Do you provide regulatory documentation for L-rhamnose?
Yes-FDA GRAS letters, EU food additive dossiers, COA, MSDS, and DMF files for pharmaceuticals. This cuts your market entry time by 50%.
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