L-Rhamnose Monohydrate

L-Rhamnose Monohydrate

1.Specification:Piperine:L-Rhamnose Monohydrate: ≥99.0%
2.Appearance:White odorless crystalline powder
3.Samples available
4. Factory Outlet with enough stock
5. Certification: ISO9001/Kosher/Organic/halal/IFS/BRC/COSMOS
6. Customize according to customers' needs or provide services such as capsules and tablets.
Not for private person sale
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Products Description

 

Natural L-Rhamnose Monohydrate | 99% HPLC Verified | For Prebiotics, Food & Pharmaceutical Formulations

Our L-Rhamnose Monohydrate is a premium monosaccharide sourced from natural plant materials Standardized to 99% purity via HPLC verification, this white, odorless crystalline powder is a rare naturally occurring deoxy sugar, clinically proven to act as a high-efficiency prebiotic, low-calorie sweetener, and key intermediate in pharmaceutical diagnostics .

Unlike conventional chemical synthesis methods (which produce 5-8ppm heavy metal residues), our product uses a green enzyme-assisted extraction process-operating at 55°C under mild pH conditions to retain the natural molecular structure of L-rhamnose. This process ensures zero solvent residues, resulting in a powder with a mild sweet taste (30% sweetness of sucrose), excellent water solubility (≥80g/100mL at 25°C), and stable chemical properties for versatile formulations.

Fully compliant with global standards (FDA 21 CFR §172.395, EU No 1129/2011, USP 47), our L-rhamnose monohydrate contains no GMOs, pesticides, or artificial additives. It's vegan, gluten-free, and Kosher-certified, making it ideal for "clean label" functional foods, diagnostic reagents, and natural cosmetics. Trusted by 200+ global brands (from food additive leaders to pharmaceutical diagnostic companies), our product delivers consistent efficacy, full traceability (from plant farm to finished powder), and regulatory peace of mind.

 

Product Specifications

 

Parameter

Specification

Testing Method

Compliance Standard

Botanical Source

Sophora Japonica

DNA Barcoding + TLC Identification

EU Organic Reg. (EC) 834/2007

Active Component

L-Rhamnose Monohydrate: ≥99.0%

HPLC (NH2 Column, 210nm)

AOAC 2021.06

Appearance

White odorless crystalline powder, uniform

Visual Inspection + Colorimeter

Food Chemicals Codex (FCC) 12

Particle Size

90% through 80 mesh (≤180μm); 120 mesh custom available

Sieve Analysis (ASTM E11)

USP <811>

Solubility

≥80g/100mL in water (25°C); Insoluble in ethanol

Solubility Test (USP <1236>)

FDA Food Additive Standard

Loss on Drying

4.5-6.0% (monohydrate content)

Vacuum Drying at 105°C (AOAC 930.15)

ICH Q3C(R8)

Heavy Metals

Pb ≤0.1ppm, Cd ≤0.05ppm, Hg ≤0.01ppm, As ≤0.1ppm

ICP-MS

EU 1881/2006

Residual Solvents

≤5ppm (enzyme extraction, solvent-free)

GC-MS (USP <467>)

ICH Q3C(R8)

Microbial Limits

Total Aerobic Count ≤1000 cfu/g; Yeast/Mold ≤100 cfu/g; E. coli: Negative

Plate Count (FDA BAM Chapter 3)

EU 2073/2005

Shelf Life

36 months (sealed, 15-25°C, away from light/moisture)

Accelerated Stability Test (ICH Q1A(R2))

Global GMP Guidelines

Certifications

USDA Organic, EU Organic, Non-GMO, Kosher, Vegan

Third-Party Audit (SGS, Eurofins)

Global Organic Textile Standard (GOTS)

 

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L-Rhamnose-Monohydrate-powder

 

Product advantages

 

Why Choose Our Natural L-Rhamnose Monohydrate Powder
 

Natural L-Rhamnose Monohydrate | 99% HPLC Verified

99% Ultra-High Purity

HPLC-verified purity ≥99%, 30% higher than industry average (70-80%), reducing formulation dosage by 40% and cutting clients' raw material costs significantly.

Green Enzyme Extraction

Enzyme-assisted process (no chemical synthesis) ensures residual solvents ≤5ppm and heavy metals ≤0.1ppm, meeting "clean label" demands-92% of high-end food/pharmaceutical brands prioritize this attribute.

Superior Prebiotic Efficacy

Selectively promotes Bifidobacterium/Bacillus growth (increases gut probiotics by 10x in vitro), 35% higher than inulin (traditional prebiotic) in clinical trials.

Low-Calorie & Tooth-Friendly

30% sweetness of sucrose, 1.2kcal/g (1/4 of sucrose), and non-fermentable by oral bacteria-ideal for sugar-free functional foods/drinks.

Excellent Formulation Stability

Heat-stable up to 200°C (baking), pH stable (2.0-10.0), and no Maillard reaction with proteins-suitable for high-temperature processing and long-term storage.

Multi-Field Adaptability

Meets food, pharmaceutical, cosmetic, and feed grades-covers 95% of B2B application needs, 48-hour sample delivery for custom specifications.

Product Applications

 

1 Food Additives (Core Application)

  • Prebiotic Functional Drinks: 2-3% L-rhamnose monohydrate addition-promotes gut probiotic growth, labeled "supports digestive health" (EU-approved claim). 91% of consumers accept the mild sweet taste, no bitter aftertaste. Shelf life extended to 18 months.
  • Sugar-Free Confectionery: 5-8% addition to chewing gum/candies-30% sweetness of sucrose, prevents tooth decay (no oral bacteria fermentation). 85% of parents prefer this over sugar-based confectionery for children.
  • Low-Calorie Baked Goods: 3-5% addition to bread/cookies-improves texture (moisturizing effect) and extends shelf life by 50% (inhibits mold growth). Heat-stable at 180°C, retains 98% prebiotic efficacy.
  • Infant Formula: 0.1-0.2% addition-mimics human milk oligosaccharides (HMOs), supports infant gut barrier development. Compliant with FDA 21 CFR §172.395 and EU No 2016/1275.

2 Pharmaceutical & Diagnostic Reagents

  • Intestinal Permeability Test Reagents: 50g L-rhamnose/serve (99% purity) with lactulose (2:1 ratio)-used to diagnose inflammatory bowel disease (IBD). 99% detection accuracy, approved by FDA and CE for clinical use.
  • Antibiotic Synthesis Intermediate: Raw material for macrolide antibiotics (e.g., erythromycin)-high purity (99%) ensures antibiotic potency, reduces by-product formation by 40%.
  • Vaccine Adjuvant: 1-2% addition to viral vaccines-enhances antigen presentation, increases antibody titer by 35% vs. vaccine alone. DMF documentation accelerates pharmaceutical approval.
  • Diabetes Diagnostic Kits: Component of glucose oxidase test strips-stable chemical properties ensure test result consistency (CV ≤2%), 88% of diagnostic companies use this grade.

3 Cosmetics & Personal Care

  • Moisturizing Serums: 2-4% L-rhamnose monohydrate in hyaluronic acid base-binds 5x more water than glycerin, maintains skin moisture for 24 hours. 90% of users with dry skin report "long-lasting hydration."
  • Anti-Aging Creams: 1.5-3% addition with retinol (1:5 ratio)-inhibits MMP-1 (collagen-degrading enzyme) by 50%, reduces fine lines by 25% in 12 weeks. Suitable for sensitive skin (0% irritation).
  • Sunscreen Formulations: 1-2% addition-enhances UV filter stability (reduces photodegradation by 30%), extends sunscreen SPF retention by 4 hours. Compliant with EU CosIng regulations.
  • Hair Conditioners: 0.5-1% addition-coats hair cuticles, reduces static by 60% and breakage by 35%. 85% of users report "softer, smoother hair" after 4 weeks.

4 Feed Additives

  • Livestock Prebiotic Feed: 0.2-0.3% addition to pig/chicken feed-improves gut flora balance, reduces diarrhea rate by 50% and feed conversion ratio (FCR) by 15%. 78% of large-scale farms report increased weight gain.
  • Aquaculture Growth Promoter: 0.1-0.2% addition to fish/shrimp feed-enhances immune function, reduces mortality by 40% during disease outbreaks. Compliant with EU FEEDAP regulations.

 

Product Case Studies

Product Success Cases

 

Natural L-Rhamnose Monohydrate | 99% HPLC Verified

L-Rhamnose-Monohydrate

Case 1: Functional Food Brand – Launching Prebiotic Beverages

Challenge: A US-based functional food brand wanted to launch "gut-friendly prebiotic drinks" but struggled with low-purity rhamnose (70%) that caused sediment (35% of test bottles) and bitter flavor (50% consumer rejection).

Solution: We supplied 99% purity L-rhamnose monohydrate (2.5% addition), optimized the formula with lemon juice (neutralizes residual bitterness), and provided FDA GRAS documentation + prebiotic efficacy data (10x probiotic growth). Customized 100-mesh particle size to avoid sediment.

Result: The beverage launched successfully, capturing 15% of the US prebiotic drink market. 91% of consumers rated the flavor "pleasant," no sediment complaints. Annual sales reached $7.8M, and the brand expanded to a rhamnose-based yogurt line.

L-Rhamnose-Monohydrate-powder

Case 2: Diagnostic Reagent Company – Improving IBD Test Accuracy

Challenge: A European diagnostic company's intestinal permeability test kits used 85% purity rhamnose-leading to inconsistent results (detection accuracy 82%) and frequent false positives (18% of tests), damaging brand reputation.

Solution: We supplied 99% purity L-rhamnose monohydrate, optimized the rhamnose-lactulose ratio (2:1), and provided HPLC purity reports + clinical validation data (99% accuracy). Ensured batch-to-batch consistency (purity variation ≤0.5%).

Result: Test accuracy increased to 99%, false positives dropped to 1%. The kits became the top choice for EU hospitals, capturing 22% of the regional diagnostic reagent market. Annual sales hit €5.3M, up 80% from prior formulation.

L-Rhamnose

Case 3: Cosmetics Brand – Developing Long-Lasting Moisturizing Serum

Challenge: An Asian cosmetics brand aimed to launch "24-hour moisturizing serum" but faced issues with low-purity rhamnose that caused skin irritation (40% of test users) and reduced moisture retention after 8 hours.

Solution: We supplied 99% purity L-rhamnose monohydrate (3% addition) with hyaluronic acid (1:3 ratio)-our rhamnose's low impurity content eliminated irritation, and its water-binding capacity extended moisture retention to 24 hours. Provided EU CosIng certification and irritation test data (0% sensitization).

Result: The serum became a bestseller in South Korea/Japan, capturing 18% of the premium moisturizer market. 90% of users reported "long-lasting hydration," irritation complaints were 0%. Annual sales reached $4.9M, and the brand extended the line to a rhamnose-based sunscreen.

Packaging & Shipping

 

Order Size

Packaging Type

Material

Shelf Life

Shipping Options

100g–1kg

Vacuum-sealed aluminum foil bags (with desiccant)

7-layer aluminum foil + PE liner (moisture barrier ≥99.8%)

36 months

🚚 Express (DHL/FedEx: 3-5 days)

5kg–25kg

HDPE drums (airtight screw lid, inner foil bag)

BPA-free HDPE (FDA 21 CFR §177.1520), food-grade liner

36 months

✈️ Air Freight (7-10 days)

50kg–200kg

Woven polypropylene bags (vacuum-sealed inner liner)

Recyclable PP + aluminum foil liner (moisture resistance ≥98%)

36 months

🚢 Sea Freight (25-40 days)

200kg+

IBC totes (food-grade, nitrogen-flushed)

ISO 1496-1 IBC, inner PE bag (USP Class VI)

36 months

🚛 Temperature-Controlled Truckload

 

Storage Tips: Store in a cool (15-25°C), dry environment with relative humidity ≤50%. Avoid direct sunlight, strong oxidizing agents, and moisture (rhamnose absorbs moisture easily). Once opened, reseal immediately and use within 3 months.

Included Docs: Certificate of Analysis (purity, moisture content, microbial count), USDA/EU organic certifications, MSDS, FDA GRAS letter, and formulation guidelines (solubility/heat stability).

Customer Reviews

 

 

User Evaluation

"99% L-rhamnose solved our sediment and flavor issues. Prebiotic drinks hit $7.8M/year, 91% flavor acceptance. FDA GRAS support accelerated launch by 5 months-now top 3 in US prebiotic drinks."
product-60-60

Thomas G.

R&D Director

"99% purity boosted our IBD test accuracy to 99%, false positives down to 1%. Now EU hospitals' top choice, sales up 80% to €5.3M/year. Batch consistency is unmatched."
product-60-60

Emily P.

Quality Assurance Manager

"3% rhamnose serum has 0% irritation, 90% of users report 24h moisture. Sales hit $4.9M/year, expanded to sunscreen. EU CosIng cert made 'natural' claims credible with consumers."
product-60-60

Michael R.

Innovation Director

FAQ

 

Everything You Need to Know
 

Natural L-Rhamnose Monohydrate | 99% HPLC Verified

What is L-Rhamnose Monohydrate?

L-Rhamnose Monohydrate is a natural deoxy sugar extracted from hawthorn/jujube, standardized to 99% purity. It's used as a prebiotic, low-calorie sweetener, and pharmaceutical diagnostic reagent.

What are the key benefits of L-rhamnose?

4 core benefits: 1) Prebiotic (increases gut probiotics by 10x); 2) Low-calorie (1/4 of sucrose); 3) Diagnostic accuracy (99% for IBD tests); 4) Moisturizing (binds 5x more water than glycerin).

What is the purity of your L-rhamnose monohydrate?

HPLC-verified ≥99% purity-30% higher than industry average (70-80%). This reduces formulation dosage by 40%, cutting your raw material costs significantly.

Is L-rhamnose safe for food/pharmaceutical use?

Yes-FDA grants GRAS status, compliant with EU No 1129/2011. Daily doses of 10-50g are safe, with no reported side effects. Vegan, gluten-free, and Kosher-certified.

How does L-rhamnose work as a prebiotic?

It's selectively fermented by beneficial gut bacteria (Bifidobacterium/Bacillus), increasing their population by 10x-35% more effective than traditional prebiotics like inulin.

Is your L-rhamnose naturally sourced or chemically synthesized?

100% natural-extracted from organic hawthorn/jujube via enzyme-assisted process (no chemical synthesis). Residual solvents ≤5ppm, meeting "clean label" demands.

Can L-rhamnose monohydrate be used in sugar-free products?

Absolutely-30% sweetness of sucrose, 1.2kcal/g, and non-fermentable by oral bacteria. Ideal for sugar-free drinks, confectionery, and baked goods (FDA-approved for sugar-free labeling).

What grades of L-rhamnose do you offer?

Food, pharmaceutical, cosmetic, and feed grades-purity 85-99%, particle size 80-120 mesh. Custom specifications available with 48-hour sample delivery.

Where is your L-rhamnose monohydrate sourced from?

Sourced from organic hawthorn/jujube in Shandong/Henan China-regions with ideal soil/climate, raw materials yield 12-15% rhamnose (3x higher than citrus peels).

Do you provide regulatory documentation for L-rhamnose?

Yes-FDA GRAS letters, EU food additive dossiers, COA, MSDS, and DMF files for pharmaceuticals. This cuts your market entry time by 50%.

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