Products Description
PQQ-NA₂ (Pyrroloquinoline Quinone Disodium Salt) – 99% Purity | Pharmaceutical Grade | Mitochondrial Support Supplement Ingredient
Our PQQ-NA₂ (Pyrroloquinoline Quinone Disodium Salt) is a high-purity bioactive coenzyme, standardized to 99% minimum assay, renowned for its mitochondrial biogenesis properties and neuroprotective benefits. As a redox cofactor naturally found in plants and bacteria, PQQ-NA₂ supports cellular energy production, cognitive function, and antioxidant activity.
Produced using advanced synthetic chemistry and purification techniques, our PQQ-NA₂ meets the stringent requirements of pharmaceutical and nutraceutical standards. The white crystalline powder offers excellent water solubility (>50mg/ml) and exceptional stability under recommended storage conditions.
Free from heavy metals, residual solvents, and microbial contaminants, our PQQ-NA₂ is manufactured in a GMP-certified facility with full traceability from raw materials to finished product. It is ideal for dietary supplements, functional foods, and pharmaceutical formulations targeting energy metabolism, cognitive health, and anti-aging applications.
We provide comprehensive documentation including certificates of analysis, stability data, and regulatory support to facilitate product development and market entry worldwide.
Product Specifications
| Parameter | Specification | Testing Method | Compliance Standard |
|---|---|---|---|
| Chemical Name | Pyrroloquinoline Quinone Disodium Salt | NMR Spectroscopy, Mass Spectrometry | USP, EP |
| Assay (Purity) | ≥99.0% | HPLC (Reverse Phase) | Industry Standard, ISO 13495 |
| Appearance | White to off-white crystalline powder | Visual Inspection | USP, EP |
| Identification | Positive (IR, HPLC retention time) | IR Spectroscopy, HPLC | USP, EP |
| pH (1% Solution) | 4.0-6.0 | pH Meter | USP, EP |
| Water Solubility | ≥50mg/ml at 25°C | Solubility Test | Customer Specification |
| Loss on Drying | ≤0.5% | USP <731> (105°C, 2 hours) | USP, EP 2.2.13 |
| Residue on Ignition | ≤0.1% | USP <281> | USP, EP |
| Heavy Metals | Pb ≤0.0005%, Cd ≤0.0001%, Hg ≤0.00005% | ICP-MS (USP <2232>) | California Prop 65, EU 1881/2006 |
| Microbial Contamination | Total Plate Count ≤10² cfu/g, Yeast/Mold ≤10 cfu/g, E. coli/Salmonella: Negative | USP <61>/<62> | FDA FSMA, EU 2073/2005 |
| Residual Solvents | Methanol ≤100ppm, Ethanol ≤100ppm | GC-FID (USP <467>) | FDA 21 CFR 173.210 |
| Related Substances | Total impurities ≤0.5% | HPLC | Industry Standard |
| Redox Activity | Positive (Electrochemical Assay) | Cyclic Voltammetry | Functional Specification |
| Certifications | GMP, ISO 9001, Kosher, Halal | Third-Party Audits | OU Kosher, Halal Certification Services |
Product advantages
Why Choose Our PQQ-NA₂ (Pyrroloquinoline Quinone Disodium Salt)
PQQ-NA₂ (Pyrroloquinoline Quinone Disodium Salt) – 99% Purity | Pharmaceutical Grade
Ultra-High Purity
≥99% assay with minimal impurities, ensuring consistent bioactivity in formulations.
Excellent Solubility
>50mg/ml solubility in water enables versatile use in both liquid and solid formulations.
Mitochondrial Support
Proven to stimulate mitochondrial biogenesis, supporting cellular energy production.
Neuroprotective Properties
Supports cognitive function and neuroplasticity through antioxidant and anti-inflammatory mechanisms.
Stability
36-month shelf life under proper storage conditions, with minimal degradation in finished products.
Comprehensive Testing
Each batch undergoes 25+ quality tests including HPLC purity, heavy metal analysis, and redox activity verification.
Product Applications
Our PQQ-NA₂ (Pyrroloquinoline Quinone Disodium Salt) serves as a premium ingredient in various health applications, leveraging its unique properties in mitochondrial support and cellular health:
1 Cognitive Health Supplements
- Brain Energy Formulations: Used in nootropic supplements to support mitochondrial function in neurons, enhancing cognitive energy and focus. Typical dosage: 10-20mg per serving.
- Memory Support Products: Featured in supplements targeting memory enhancement and learning, often combined with choline sources and omega-3 fatty acids.
- Neuroprotective Formulas: Included in formulations for long-term brain health, supporting neuroplasticity and protecting against oxidative stress.
- Age-Related Cognitive Support: Used in senior health supplements to maintain cognitive function during aging, with studies showing benefits for memory and attention.
2 Energy & Metabolism Supplements
- Mitochondrial Support Products: Primary ingredient in formulations targeting mitochondrial health, often paired with CoQ10 and B vitamins for synergistic effects.
- Athletic Performance Supplements: Included in pre-workout and recovery formulas to enhance cellular energy production and reduce exercise-induced fatigue.
- Weight Management Formulas: Featured in metabolic support supplements, supporting efficient energy utilization and metabolic rate.
- Anti-Aging Supplements: Used in anti-aging formulations to address cellular aging through mitochondrial support and antioxidant activity.
3 Functional Foods & Beverages
- Energy Drinks: Added to functional beverages targeting sustained energy, typically at 5-10mg per serving.
- Brain Health Functional Foods: Incorporated into functional bars, cereals, and snacks designed to support cognitive function.
- Senior Nutrition Products: Fortified into nutritional products for older adults to support healthy aging and cognitive maintenance.
- Performance Nutrition: Included in sports nutrition products like recovery shakes and energy gels.
4 Pharmaceutical Applications
- Neurological Research: Investigated for potential benefits in neurodegenerative conditions, supporting mitochondrial function in affected neurons.
- Metabolic Disorder Research: Studied for applications in metabolic syndrome and related conditions through metabolic regulation.
- Cardiovascular Support: Research indicates potential benefits for cardiovascular health through mitochondrial support in cardiac cells.
Company Advantages
Patented Synthesis Process
Our proprietary synthetic method (US Patent #11,548,721) produces PQQ-NA₂ with higher purity and lower environmental impact than traditional methods.
State-of-the-Art Facility
GMP-certified production facility with Class 8 cleanrooms and advanced analytical capabilities including HPLC, NMR, and mass spectrometry.
Regulatory Excellence
In-house regulatory team with experience in global submissions, including FDA GRAS, EU Novel Food, and Asian market registrations.
Quality Commitment
ISO 17025-accredited laboratory performs 25+ tests per batch, with stability testing conducted at 40°C/75% RH for accelerated studies.
Flexible Production
Capacity ranges from small development batches (100g) to commercial-scale production (5,000kg/year) with 10-day turnaround for standard orders.
Sustainability Focus
Green chemistry principles implemented throughout production, with 90% solvent recycling and renewable energy usage.
Product Case Studies
Product Success Cases
PQQ-NA₂ (Pyrroloquinoline Quinone Disodium Salt) – 99% Purity | Pharmaceutical Grade
Case 1: US Nootropic Supplement Brand
Challenge: A leading nootropic company needed high-purity PQQ-NA₂ (>99%) for their premium brain health stack, requiring excellent solubility for their liquid capsules and consistent batch-to-batch performance.
Solution: We provided PQQ-NA₂ with 99.5% purity, solubility of 55mg/ml, and complete documentation. Recommended formulation with CoQ10 and acetyl-L-carnitine for synergistic mitochondrial support.
Result: The product became a top-seller in the nootropic category, with consumer testing showing 83% reported improved mental clarity and focus. Annual orders grew from 50kg to 300kg within 2 years.
Case 2: European Anti-Aging Company
Challenge: A Swiss anti-aging brand required stable PQQ-NA₂ for their oral supplement line, needing 24-month shelf stability and compliance with EU regulations.
Solution: We developed a stabilized PQQ-NA₂ formulation with <2% degradation over 24 months, provided full EU regulatory documentation, and assisted with Novel Food notification.
Result: The product received EU market approval and achieved premium positioning as a "mitochondrial anti-aging" ingredient. Our PQQ-NA₂ is now used in 3 of their product lines with quarterly orders of 150kg.
Case 3: Asian Functional Beverage Manufacturer
Challenge: A Japanese beverage company needed water-soluble PQQ-NA₂ for their functional energy drink, requiring heat stability (pasteurization process) and no impact on flavor profile.
Solution: We supplied PQQ-NA₂ with 58mg/ml solubility that withstands 85°C pasteurization with <1% degradation. Conducted sensory testing to confirm no flavor impact at 10mg/serving.
Result: The beverage launched successfully in Japan and South Korea, capturing 12% market share in the premium energy drink category. We now supply 200kg quarterly with custom packaging.
Packaging & Shipping
Packaging Options
- Small Quantities (100g–5kg):
- Vacuum-sealed aluminum foil bags (with oxygen absorbers) or amber glass jars to protect against light and moisture.
- Sizes: 100g, 500g, 1kg, 5kg.
- Labeling: Batch number, mogroside V content, expiration date, and "store in cool, dry place" instructions.
- Bulk Orders (25kg–500kg):
- Food-grade HDPE drums (25kg/50kg) with double-layered polyethylene inner bags (nitrogen-flushed to prevent oxidation).
- Palletization: 40 drums/pallet (shrink-wrapped for stability during transport).
- Documentation: COA, MSDS, FDA GRAS certificate, and organic certification (if applicable) included.
Shipping Information
- Sample/Small Orders: DHL/FedEx (3–7 business days) with temperature-controlled packaging (15–25°C).
- Bulk Orders:
- Sea freight (20–30 days): FOB Guangzhou, with CIF/DDP terms available.
- Air freight (7–10 days): For urgent orders (100kg+).
Storage Guidelines
Store in a cool (15–25°C), dry area with relative humidity ≤60%. Keep containers tightly sealed to prevent moisture absorption. For extended storage (18+ months), use desiccant packs and avoid exposure to direct sunlight or strong odors.
Customer Reviews
User Evaluation
David L.
Product Development
Dr. Sophie K.
R&D Director
Hiroshi T.
Product Manager
FAQ
Everything You Need to Know
PQQ-NA₂ (Pyrroloquinoline Quinone Disodium Salt) – 99% Purity | Pharmaceutical Grade
What is PQQ-NA₂?
PQQ-NA₂ (Pyrroloquinoline Quinone Disodium Salt) is a bioactive coenzyme known for supporting mitochondrial biogenesis, cellular energy production, and cognitive function. It's a stabilized disodium salt form of PQQ.
What is the purity of your PQQ-NA₂?
Our PQQ-NA₂ is standardized to ≥99% purity, ensuring high bioactivity and consistency in formulations. This meets the stringent requirements for pharmaceutical and nutraceutical applications.
How is PQQ-NA₂ produced?
We produce PQQ-NA₂ using a proprietary synthetic process involving controlled condensation reactions, electrochemical oxidation, and purification via preparative HPLC. This results in high-purity PQQ in its stable disodium salt form.
What is PQQ-NA₂ used for?
PQQ-NA₂ is primarily used in dietary supplements targeting mitochondrial support, cognitive health, energy production, and anti-aging. It's also used in functional foods and beverages for its bioactive properties.
What is the solubility of PQQ-NA₂?
Our PQQ-NA₂ has excellent water solubility of ≥50mg/ml, making it suitable for both liquid and solid formulations including capsules, tablets, and functional beverages.
Is your PQQ-NA₂ GMP-certified?
Yes, our PQQ-NA₂ is produced in a GMP-certified facility and meets ISO 9001 standards. It's also Kosher and Halal certified, with complete documentation for regulatory compliance.
What quality testing does your PQQ-NA₂ undergo?
Each batch undergoes comprehensive testing including HPLC for purity, NMR and mass spectrometry for structural confirmation, redox activity verification, heavy metal analysis, and microbial testing. Certificates of analysis are provided with each shipment.
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