Products Description
Citicoline Sodium Powder – 99% Purity | USP/EP Compliant, Pharmaceutical Grade | CDP-Choline for Cognitive Health Supplements
Our Citicoline Sodium Powder (CDP-Choline) is a high-purity neuroprotective compound, standardized to 99% minimum assay, designed for cognitive health and neurological support applications. As a naturally occurring nucleotide, citicoline plays a critical role in phosphatidylcholine synthesis, supporting brain membrane integrity and neurotransmitter production.
Produced using advanced enzymatic synthesis and purification techniques, our citicoline meets the stringent requirements of USP, EP, and JP pharmacopoeias. The fine crystalline powder offers excellent solubility in water (≥200mg/ml) and exceptional stability under recommended storage conditions.
Free from heavy metals, residual solvents, and microbial contaminants, our citicoline sodium is manufactured in a GMP-certified facility with full traceability from raw materials to finished product. It is ideal for dietary supplements, functional foods, and pharmaceutical formulations targeting cognitive function, memory support, and neurological health.
We provide comprehensive documentation including certificates of analysis, stability data, and regulatory support to facilitate product development and market entry worldwide.
Product Specifications
| Parameter | Specification | Testing Method | Compliance Standard |
|---|---|---|---|
| Chemical Name | Cytidine 5'-diphosphocholine sodium salt | NMR Spectroscopy | USP, EP |
| Assay (Purity) | ≥99.0% | HPLC (USP <35> Citicoline Sodium) | USP 43, EP 10.0, JP 17 |
| Appearance | White to off-white crystalline powder | Visual Inspection | USP, EP |
| Identification | Positive (IR, HPLC retention time) | IR Spectroscopy, HPLC | USP, EP |
| pH (5% Solution) | 6.0-7.5 | pH Meter | USP, EP |
| Specific Rotation | +35° to +41° | Polarimetry | USP, EP |
| Loss on Drying | ≤1.0% | USP <731> (105°C, 3 hours) | USP, EP 2.2.13 |
| Residue on Ignition | ≤0.1% | USP <281> | USP, EP |
| Heavy Metals | Pb ≤0.001%, Cd ≤0.0005%, Hg ≤0.0001% | ICP-MS (USP <2232>) | California Prop 65, EU 1881/2006 |
| Microbial Contamination | Total Plate Count ≤10³ cfu/g, Yeast/Mold ≤10² cfu/g, E. coli/Salmonella: Negative | USP <61>/<62> | FDA FSMA, EU 2073/2005 |
| Endotoxin | ≤0.1EU/mg | LAL Test | USP <85> |
| Residual Solvents | Methanol ≤300ppm, Ethanol ≤500ppm | GC-FID (USP <467>) | FDA 21 CFR 173.210 |
| Related Substances | Cytidine ≤0.5%, Other impurities ≤0.5% | HPLC | USP, EP |
| Certifications | GMP, ISO 9001, Kosher, Halal | Third-Party Audits | OU Kosher, Halal Certification Services |
Product advantages
Why Choose Our Citicoline Sodium Powder
Citicoline Sodium Powder – 99% Purity | USP/EP Compliant, Pharmaceutical Grade
Pharmaceutical-Grade Purity
≥99% assay with minimal impurities, meeting USP, EP, and JP standards for pharmaceutical applications.
Superior Solubility
≥200mg/ml solubility in water enables versatile use in both liquid and solid formulations.
Advanced Synthesis
Enzymatic production method ensures optimal molecular integrity and bioactivity compared to chemical synthesis.
Neurological Efficacy
Supports phosphatidylcholine synthesis, acetylcholine production, and brain energy metabolism for cognitive health applications.
Exceptional Stability
36-month shelf life under proper storage conditions, with minimal degradation in finished products.
Comprehensive Testing
Each batch undergoes 30+ quality tests including HPLC purity, endotoxin, and heavy metal analysis.
Product Applications
Our Citicoline Sodium Powder serves as a key ingredient in various health and pharmaceutical applications, leveraging its neuroprotective and cognitive-supporting properties:
1 Cognitive Health Supplements
- Memory Support Formulations: Used in supplements targeting memory enhancement and cognitive function, typically at 250-1000mg daily dosages. Clinical studies show citicoline supports memory recall and learning ability.
- Brain Energy Products: Featured in nootropic supplements to support ATP production in brain cells, helping maintain mental energy and focus during periods of cognitive demand.
- Age-Related Cognitive Support: Included in senior health supplements to support healthy cognitive aging, with research indicating benefits for age-related memory decline.
- Stress & Focus Supplements: Combined with adaptogens like ashwagandha in formulations designed to support cognitive function during stress and improve attention span.
2 Neurological Pharmaceutical Applications
- Stroke Recovery Medications: Used in prescription formulations to support neurological recovery after ischemic stroke, helping restore choline levels and membrane integrity.
- Neurodegenerative Disease Support: Investigated for potential benefits in neurodegenerative conditions, with studies showing support for neuronal membrane stability.
- Traumatic Brain Injury Formulations: Included in medical products for supporting cognitive recovery following traumatic brain injury.
- Ophthalmic Products: Used in eye drops and formulations for retinal health, leveraging its role in phosphatidylcholine synthesis for cell membrane support.
3 Functional Foods & Beverages
- Brain Health Functional Foods: Added to functional bars, cereals, and snacks targeting cognitive health, typically at 100-500mg per serving.
- Nootropic Beverages: Featured in ready-to-drink brain health beverages and powdered drink mixes, often combined with vitamins B6, B12, and caffeine.
- Medical Nutrition: Included in clinical nutrition products for patients with neurological conditions or recovering from brain injuries.
4 Sports Nutrition
- Cognitive Performance Formulas: Used in pre-workout supplements to support focus and mental clarity during physical performance.
- Recovery Products: Included in post-workout formulations to support overall neurological recovery after intense exercise.
Company Advantages
Patented Production Process
Our enzymatic synthesis method (US Patent #10,457,782) produces citicoline with higher purity and lower environmental impact than traditional chemical synthesis.
State-of-the-Art Facility
GMP-certified production facility with Class 8 cleanrooms and advanced HPLC, NMR, and FT-IR testing capabilities.
Regulatory Excellence
In-house regulatory team with experience in global submissions, including FDA DMF, EMA CEP, and JDMF filings.
Quality Commitment
ISO 17025-accredited laboratory performs 30+ tests per batch, with stability testing conducted at 40°C/75% RH for accelerated studies.
Flexible Production
Capacity ranges from small development batches (1kg) to commercial-scale production (10,000kg/month) with 10-day turnaround for standard orders.
Sustainability Focus
Carbon-neutral production process with 95% water recycling and renewable energy usage (solar and wind).
Product Case Studies
Product Success Cases
Citicoline Sodium Powder – 99% Purity | USP/EP Compliant, Pharmaceutical Grade
Case 1: US Nootropic Supplement Brand
Challenge: A leading US supplement company needed high-purity citicoline (≥99%) for their premium nootropic stack, requiring excellent solubility for their liquid capsules and USP compliance.
Solution: We provided citicoline sodium with 99.5% purity, solubility of 220mg/ml, and complete USP documentation. Recommended formulation with phosphatidylserine for synergistic cognitive benefits.
Result: The product became a top-seller in the nootropic category, with consumer testing showing 87% reported improved focus within 30 minutes. Annual orders grew from 2,000kg to 8,000kg within 3 years.
Case 2: European Pharmaceutical Company
Challenge: A German pharmaceutical firm required citicoline sodium meeting EP standards for their stroke recovery medication, needing ultra-low endotoxin levels (<0.05EU/mg) and batch-to-batch consistency.
Solution: We developed a specialized pharmaceutical-grade citicoline with endotoxin levels <0.03EU/mg and related substances <0.3%. Provided full CEP documentation for EMA approval.
Result: The medication received EMA approval and is now prescribed in 12 European countries. Our citicoline's consistent quality has resulted in a 5-year supply contract with annual volumes exceeding 15,000kg.
Case 3: Asian Functional Beverage Manufacturer
Challenge: A Japanese beverage company needed stable citicoline for their ready-to-drink brain health beverage, requiring compatibility with their vitamin blend and 12-month shelf stability.
Solution: We supplied micronized citicoline sodium with enhanced dissolution rate, stability data confirming <2% degradation over 12 months, and support for Japanese regulatory approval.
Result: The beverage achieved market-leading position in Japan's functional drink category, with our citicoline as a key marketing ingredient. We now supply 5,000kg quarterly with custom packaging.
Packaging & Shipping
Packaging Options
- Small Quantities (100g–5kg):
- Vacuum-sealed aluminum foil bags (with oxygen absorbers) or amber glass jars to protect against light and moisture.
- Sizes: 100g, 500g, 1kg, 5kg.
- Labeling: Batch number, mogroside V content, expiration date, and "store in cool, dry place" instructions.
- Bulk Orders (25kg–500kg):
- Food-grade HDPE drums (25kg/50kg) with double-layered polyethylene inner bags (nitrogen-flushed to prevent oxidation).
- Palletization: 40 drums/pallet (shrink-wrapped for stability during transport).
- Documentation: COA, MSDS, FDA GRAS certificate, and organic certification (if applicable) included.
Shipping Information
- Sample/Small Orders: DHL/FedEx (3–7 business days) with temperature-controlled packaging (15–25°C).
- Bulk Orders:
- Sea freight (20–30 days): FOB Guangzhou, with CIF/DDP terms available.
- Air freight (7–10 days): For urgent orders (100kg+).
Storage Guidelines
Store in a cool (15–25°C), dry area with relative humidity ≤60%. Keep containers tightly sealed to prevent moisture absorption. For extended storage (18+ months), use desiccant packs and avoid exposure to direct sunlight or strong odors.
Customer Reviews
User Evaluation
Mark T.
Product Development Director
Dr. Sophie L.
Quality Assurance
Kenji N.
Quality Assurance
FAQ
Everything You Need to Know
Citicoline Sodium Powder – 99% Purity | USP/EP Compliant, Pharmaceutical Grade
What is Citicoline Sodium Powder?
Citicoline Sodium Powder (CDP-Choline) is a high-purity nucleotide compound essential for brain health, supporting phosphatidylcholine synthesis and neurotransmitter production. It's used in supplements and pharmaceuticals for cognitive support.
What is the purity of your Citicoline Powder?
Our citicoline sodium powder is standardized to ≥99% purity, meeting USP, EP, and JP pharmacopoeial standards. This high purity ensures consistent bioactivity and reliability in formulations.
How is Citicoline Powder produced?
We use an advanced enzymatic synthesis process using high-purity cytidine monophosphate and choline phosphate. This method produces citicoline with higher purity and fewer impurities than traditional chemical synthesis.
What is Citicoline Powder used for?
Citicoline is primarily used in cognitive health supplements to support memory, focus, and overall brain function. It's also used in pharmaceutical formulations for neurological support and recovery.
What is the solubility of Citicoline Sodium?
Our citicoline sodium powder has excellent solubility of ≥200mg/ml in water, making it suitable for both liquid and solid formulations including capsules, tablets, and beverages.
Is your Citicoline GMP-certified?
Yes, our citicoline sodium is produced in a GMP-certified facility and meets ISO 9001 standards. It's also Kosher and Halal certified, with complete documentation for regulatory compliance.
What quality testing does your Citicoline undergo?
Each batch undergoes comprehensive testing including HPLC for purity, NMR for structural confirmation, LAL test for endotoxins, microbial testing, and heavy metal analysis. Certificates of analysis are provided with each shipment.
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