Bulk Spermidine Trihydrochloride Powder (Spermidine 3HCl)
Ultra-Pure Cellular Autophagy Activator · Pure Synthetic & Enzymatic Grade · Premium Crystalline Powder for Longevity Supplements
R&D Insights: Free Base Spermidine vs. Spermidine Trihydrochloride
Why formulation experts strongly prefer Spermidine 3HCl for encapsulated products.
If you have ever attempted to formulate anti-aging supplements with botanical wheat germ extracts or free-base spermidine, you likely encountered two major industry pain points: extremely low active content (often less than 1%) and extreme hygroscopicity leading to powder caking during capsule filling.
Free-base spermidine is unstable and rapidly oxidizes when exposed to ambient humidity. By converting pure spermidine into its trihydrochloride salt form (Spermidine 3HCl), we achieve an exceptional active purity of ≥ 98.0% with significantly enhanced crystalline stability. This provides formulators with precise dosage control (e.g., 5mg to 10mg active spermidine per capsule) without carrying huge amounts of inactive botanical plant matter or suffering from moisture-induced shelf degradation.
Technical Specifications
| Chemical Name | Spermidine Trihydrochloride / N-(3-Aminopropyl)butane-1,4-diamine trihydrochloride |
| CAS No. / Molecular Formula | 334-50-9 / C7H19N3·3HCl (Molecular Weight: 254.63 g/mol) |
| Appearance & Form | White to off-white crystalline powder, free-flowing |
| Assay (Purity) | ≥ 98.0% (HPLC / Titration verified) |
| Solubility | 100% water soluble; yields a clear, transparent solution |
| Loss on Drying | ≤ 1.0% (Strictly vacuum dried for powder stability) |
| Heavy Metals & Arsenic | Heavy Metals < 10 ppm | Pb < 2 ppm | As < 1 ppm | Cd < 1 ppm | Hg < 0.1 ppm |
| Microbial Control | Total Plate Count < 1,000 cfu/g; Yeast & Mould < 100 cfu/g; E. coli / Salmonella Negative |
| Recommended Storage | 24 Months when stored in tightly sealed containers at 2–8°C away from light and humidity |
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Frequently Asked Questions (FAQ)
Q1: What is the main advantage of Spermidine 3HCl over natural wheat germ extract?
A: Natural wheat germ extract contains only 0.1% to 1.0% active spermidine, requiring consumers to swallow multiple huge capsules daily. Spermidine 3HCl delivers ≥98% active purity, enabling formulators to offer precise, high-potency daily dosages in standard 0# or 1# hard capsules.
Q2: How should Spermidine Trihydrochloride powder be handled to prevent moisture absorption?
A: Although the trihydrochloride salt form is significantly more stable than free-base spermidine, it remains slightly hygroscopic. We recommend working in a humidity-controlled cleanroom (RH < 40%) during weighing and encapsulation, and keeping unused powder tightly sealed in vacuum foil bags.
Q3: Is your Spermidine 3HCl produced by chemical synthesis or fermentation?
A: Our material is manufactured via high-efficiency, ultra-clean chemical synthesis followed by multi-stage crystallization. This method avoids unpredictable agricultural crop contaminants, heavy metals, and gluten allergens common in wheat extracts.
Q4: Is Spermidine Trihydrochloride suitable for vegan or gluten-free products?
A: Yes, 100%. Our synthetic process uses zero animal-derived raw materials and zero grain inputs. It is certified 100% Vegan, Gluten-Free, and Non-GMO.
Q5: What is the Minimum Order Quantity (MOQ) for bulk testing?
A: Our MOQ for trial pilot testing is 1 kg in a vacuum-sealed foil bag. We also offer 10g–50g sample kits for initial lab testing and analytical qualification.
Q6: How can our technical team request a sample and COA?
A: Simply click the inquiry button below or contact our sales engineers. We will provide a complete technical package including batch-specific COA, HPLC spectra, and sample dispatch within 24 hours.
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