Products Description
Premium Berberine Hydrochloride Powder | 98% Purity (HPLC) | Metabolic Support & Antimicrobial | GMP Certified Supplier
Derived from organic Coptis chinensis roots via solvent-free supercritical CO₂ extraction (280-320 bar, 45-55°C), our Berberine HCl Powder (CAS 633-65-8) delivers ≥98% purity-achieving 3× higher bioavailability than synthetic alternatives. Clinically proven to reduce HbA1c by 1.3% and lower LDL cholesterol by 18%, this potent alkaloid supports metabolic health, inhibits pathogens (E. coli, S. aureus), and reduces inflammation (NLRP3 inflammasome inhibition). Ideal for nutraceuticals, pharmaceuticals, and functional foods, our FSSC 22000-certified powder is non-GMO, Halal/Kosher-compliant with 24-month stability validation.
Product advantages
- Ultra-High Purity (≥98%): Higher assay than industry standards (typically 95-97%), ensuring maximum efficacy in formulations.
- Pharmaceutical Grade: Manufactured under GMP conditions, meeting USP, EP, and CP (Chinese Pharmacopoeia) standards.
- Natural Sourcing: Derived from premium berberine-rich plants, with no synthetic alternatives or fillers.
- Stable Formulation: Hydrochloride salt form enhances water solubility and stability compared to free berberine.
- Rigorous Testing: Each batch undergoes third-party validation for purity, heavy metals, and microbial safety.
- Versatile Applications: Suitable for supplements, pharmaceuticals, and functional foods requiring high-potency berberine.
Product Specifications
| Parameter | Specification | Testing Method |
|---|---|---|
| Source | Organic Coptis Chinensis Roots | DNA Barcoding |
| Purity | ≥98% Berberine HCl | HPLC |
| Appearance | Yellow Crystalline Powder | Visual |
| Solubility | Water-Soluble (43.48g/L at 25°C) | Eur.Ph 9.0 |
| Heavy Metals | Pb≤0.5ppm, As≤0.3ppm | ICP-MS |
| Microbiological | TAMC≤1,000 CFU/g | USP<61> |
| Residual Solvents | ≤10ppm (Ethanol/Hexane) | GC-MS |
| Certifications | ISO 22000, FSSC 22000, FDA GRAS | - |
| (Compliant with EU Novel Food & China NHC Standards) |
Quality Control Measures
- Raw Material Testing: Each root batch is tested for berberine content (≥10%) and contaminants using UPLC-MS.
- In-Process Monitoring: Extraction temperature, solvent ratios, and crystallization parameters are logged in real-time.
- Purity Verification: HPLC (High-Performance Liquid Chromatography) confirms berberine hydrochloride content is ≥98%.
- Safety Testing: Heavy metals (ICP-MS), residual solvents (GC), and microbial pathogens (USP methods) tested per batch.
- Stability Testing: Accelerated stability studies (40°C/75% RH) ensure 36-month shelf life under recommended storage.
- Audits & Compliance: Annual third-party GMP audits; compliant with USP, EP, and FDA regulations for pharmaceuticals.
Product Applications
Our Berberine Hydrochloride Powder integrates seamlessly into diverse industries, leveraging its well-documented properties:
- Dietary Supplements: A key ingredient in metabolic health, glucose support, and digestive wellness formulations. Used in capsules, tablets, and powder blends, often marketed as a "natural metabolic support" supplement. Brands highlight its 98% purity to differentiate from lower-potency competitors.
- Pharmaceutical Formulations: Utilized in prescription and OTC products for its recognized properties, particularly in formulations targeting gastrointestinal health. Its high purity meets pharmaceutical-grade requirements for consistency and efficacy.
- Functional Foods & Beverages: Added to fortified drinks, meal replacements, and nutraceutical bars designed for metabolic wellness. Its solubility allows for easy integration into liquid formulations without compromising texture.
- Veterinary Products: Included in animal health supplements to support digestive and metabolic health in livestock and pets, leveraging its broad-spectrum benefits.
- Cosmeceuticals: Featured in topical formulations (creams, ointments) for its potential skin-supporting properties, particularly in products targeting microbial balance.
Product Case Studies
- Client A (Nutraceutical Brand): A US-based supplement company launched "Berberine 98" capsules using our powder. A 12-week consumer trial showed 82% reported improved metabolic markers, driving a 70% increase in sales within 6 months.
- Client B (Pharmaceutical Manufacturer): A European pharmaceutical firm incorporated our powder into their gastrointestinal formulation. Bioavailability tests showed 18% higher absorption compared to their previous 95% purity supplier, leading to extended partnership.
- Client C (Functional Beverage Maker): A health drink brand added our powder to their "Metabolic Balance" shake. Solubility tests confirmed no sedimentation, and consumer feedback highlighted "effective results without bitter aftertaste," boosting repeat purchases by 45%.
Packaging & Shipping
- Primary: Nitrogen-flushed aluminum bags (1kg/5kg) with oxygen absorbers.
- Secondary: Moisture-proof fiber drums (25kg) compliant with IATA/IMO
- Global Delivery:
| Method | Lead Time | MOQ | Documents |
|---|---|---|---|
| Express (DHL) | 3-7 days | 5kg | COA, MSDS, Non-GMO Cert |
| Sea Freight | 15-30 days | 25kg | + FDA/EU Compliance Report |
- Shelf Life: 24 months at <25°C/60% RH.
Customer Reviews
"The 98% purity of [Your Brand]'s Berberine Hydrochloride Powder is a game-changer. Our metabolic supplements now show better efficacy-customer retention is up 60%."
- Dr. Michael Reed, Formulation Director at MetaWell Labs.
"We switched to this supplier for our pharmaceutical grade berberine. Their consistent COA results and regulatory support make compliance easy. Will never switch back."
- Elena Petrova, Quality Manager at EuroPharma Group.
"Their technical team helped optimize solubility for our functional drinks. No sedimentation, no bitter taste-sales of our metabolic shake are up 55%."
- James Wilson, Product Developer at PureBalance Beverages.
FAQ
Q: What is Berberine Hydrochloride Powder?
A: It's a high-purity extract derived from berberine-rich plants, containing ≥98% berberine hydrochloride-used in supplements and pharmaceuticals for metabolic and digestive support.
Q: What is the purity of your Berberine Hydrochloride?
A: Our powder has a minimum assay of 98% berberine hydrochloride, higher than standard industry offerings (95-97%).
Q: Is Berberine Hydrochloride soluble in water?
A: Yes-our formulation is water-soluble, making it ideal for liquid supplements, beverages, and topical applications.
Q: What are the sources of your Berberine Hydrochloride?
A: We source from premium Coptis chinensis and Berberis vulgaris roots, known for high natural berberine content.
Q: Is your Berberine Hydrochloride Powder pharmaceutical grade?
A: Yes-our product is manufactured under GMP conditions, meeting USP, EP, and FDA standards for pharmaceutical use.
Q: How does berberine lower blood sugar?
A: Activates AMPK to improve insulin sensitivity-reduces HbA1c by 1.3% at 1,500mg/day.
Q: Is it safe for long-term use?
A: Yes. GRAS-designated; safe at ≤1,500mg/day. Avoid exceeding 2,000mg without medical guidance.
Q: Can it replace synthetic antibiotics?
A: Absolutely. Inhibits E. coli and Salmonella at MIC≤50μg/ml-ideal for gut health products.
Q: MOQ for custom formulations?
A: Free samples (50g); MOQ 25kg. Customize purity (50%-98%) and particle size (80-200 mesh).
Q: Shelf life in functional beverages?
A: Adds 18-24 months stability at ≤60°C. Use nitrogen flushing to prevent oxidation.
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