Products Description

Parthenolide is a chemical compound extracted from Pyrethrum parthenium (L.) J.G.Sm. Feverfew Extract Parthenolide powder is a natural product of sesquiterpene lactones, isolated from medicinal plants such as Aiju and Sightseeing Tree, which are widely used in fever, deworming, and anti-inflammatory effects. In recent years, studies have confirmed that paeonolactone has a variety of important pharmacological activities, such as anti-tumor, anti-virus, anti-inflammatory and anti atherosclerosis. Traditionally, paeonolactone is mainly used to treat migraine, fever and rheumatoid arthritis.

Product Name	Parthenolide powder
Appearance	White Powder
Specification	Parthenolide: ≥98% (HPLC); 0.3%-3%, 99% HPLC Parthenolides
Grade	Food grade
Source	Chrysanthemum parthenium(flower)
Application	Medicine, Food additive, Beverages, Cosmetic Field, and Healthcare Products
Certification	HACCP, ISO, QS, Halal, Kosher,FDA,COSMOS,IFS,BRC
Quality	Non-GMO, Non-irradiation, Allergen Free, BSE/TSE Free

Basic Analysis

Item	Specification	Conclusion
Purity (HPLC)	Parthenolide: ≥98%	100%
Appearance	White Powder	Conforms
Heavy metal
Total metals	≤10.0ppm	Conforms
Lead	≤2.0ppm	Conforms
Mercury	≤1.0ppm	Conforms
Cadmium	≤0.5ppm	Conforms
Loss on drying	≤0.5%	0.5%
Microorganism
Total number of bacteria	≤1000cfu/g	Conforms
Yeast	≤100cfu/g	Conforms
Escherichia coli	Not included	Not included
Salmonella	Not included	Not included
Staphylococcus	Not included	Not included

Features

Parthenolide has a variety of reported in vitro biological activities, including:

• Inhibition of HDAC1 protein without affecting other class I/II HDACs, which leads to sustained DNA damage response in certain cells (required for apoptosis).
• Modulation of the NF-κB-mediated inflammatory responses in experimental atherosclerosis.
• Inducing apoptosis in acute myelogenous leukemia (AML) cells, leaving normal bone marrow cells relatively unscathed. Moreover, the compound may get at the root of the disease because it also kills stem cells that give rise to AML.
• Activity against Leishmania amazonensis.
• Microtubule-interfering activity.
• Agonist of the adiponectin receptor 2 (AdipoR2).
• Inhibition of mammalian thioredoxin reductase.

Application

(1) Applied in the pharmaceutical field do medicine raw material;
(2) Applied in the health care product field;
(3) Applied in the food and water-soluble beverage field.

(4) Applied in the Cosmetic product field.