Products Description
Natural Glycyrrhetinic Acid Powder | 98% Purity | For Skincare, Pharmaceuticals & Food
Our Glycyrrhetinic Acid Powder is a premium triterpenoid compound derived. Through enzymatic hydrolysis and supercritical CO₂ extraction, the product is refined to 98% purity via HPLC verification, presenting as a white to off-white fine powder with potent anti-inflammatory, anti-irritant, and skin-soothing properties. It is a core functional ingredient in high-end cosmetics, pharmaceutical formulations, and food additives globally.
Unlike traditional acid hydrolysis (which leaves 10-15ppm acid residues and degrades active components), our process uses plant-derived enzymes to break down glycyrrhizic acid into glycyrrhetinic acid at 50°C, followed by supercritical CO₂ purification-retaining 99% of the natural molecular structure (18β-glycyrrhetinic acid, the most bioactive isomer). The finished product has a subtle licorice aroma, no bitter aftertaste, and excellent stability (tolerates 180°C processing). We offer dual solubility options (oil-soluble standard grade, water-soluble cyclodextrin complex) to fit 98% of B2B formulation scenarios.
Fully compliant with global regulations (FDA 21 CFR §172.200, EU No 1334/2008, USP 47), our glycyrrhetinic acid powder is free of GMOs, pesticides, and heavy metals (Pb≤0.1ppm). It holds USDA Organic, Kosher, and Vegan certifications, perfectly aligning with "clean label" and "sensitive skin" trends. Trusted by 220+ global brands (including Shiseido and Pfizer), we provide full traceability via QR code-tracking from licorice plantation to finished powder-to ensure regulatory peace of mind for clients in Europe, America, and Southeast Asia.
Product Specifications
|
Parameter |
Specification (Standard/Water-Soluble) |
Testing Method |
Compliance Standard |
|---|---|---|---|
|
Botanical Source |
Organic Glycyrrhiza uralensis |
DNA Barcoding + TLC Identification |
EU Organic Reg. (EC) 834/2007 |
|
Active Component |
Glycyrrhetinic Acid (18β-isomer): ≥98.0% |
HPLC (C18 Column, 254nm) | AOAC 2022.08 |
USP 47 |
|
Appearance |
White to off-white fine powder, uniform, no lumps |
Visual Inspection + Colorimeter |
Food Chemicals Codex (FCC) 12 |
|
Particle Size |
95% through 100 mesh (≤150μm); 200 mesh custom available |
Laser Diffraction (ASTM B822) |
USP <811> |
|
Solubility |
Oil-soluble: ≥30% in vegetable oil; Water-soluble: ≥20% in 25°C water |
Solubility Test (USP <1236>) |
FDA Food Additive Standard |
|
Melting Point |
292-298°C |
Differential Scanning Calorimetry (ASTM E794) |
ISO 11357-3:2018 |
|
Heavy Metals |
Pb ≤0.1ppm, Cd ≤0.05ppm, Hg ≤0.01ppm, As ≤0.1ppm |
ICP-MS |
EU 1881/2006 |
|
Residual Solvents |
≤5ppm (supercritical CO₂ extraction, solvent-free) |
GC-MS (USP <467>) |
ICH Q3C(R8) |
|
Microbial Limits (Food Grade) |
Total Aerobic Count ≤1000 cfu/g; Yeast/Mold ≤100 cfu/g; E. coli: Negative |
FDA BAM Chapter 3 |
EU 2073/2005 |
|
Shelf Life |
24 months (sealed, 15-25°C, away from light/oxygen) |
Accelerated Stability Test (ICH Q1A(R2)) |
Global GMP Guidelines |
|
Certifications |
USDA Organic, EU Organic, Non-GMO, Kosher, Vegan, ISO 22000, GMP |
Third-Party Audit (SGS, Eurofins) |
Global Organic Standards |
Product advantages
Why Choose Our Natural Glycyrrhetinic Acid Powder
Natural Glycyrrhetinic Acid Powder | 98% Purity
98% Ultra-High Purity
HPLC-verified 18β-glycyrrhetinic acid ≥98%, 35% higher than industry average (65-70%), reducing formulation dosage by 50% and cutting clients' raw material costs by 40%.
Green Enzymatic Extraction
Enzyme hydrolysis + supercritical CO₂ purification (no acid/alkali solvents) ensures residual solvents ≤5ppm-meets "clean label" demands of 95% high-end cosmetic/pharmaceutical brands.
Potent Anti-Inflammatory Activity
Inhibits COX-2 by 90% and TNF-α by 85% (vs. 60% for hydrocortisone), with no steroid side effects-ideal for sensitive skin and pediatric formulations.
Dual-Solubility Customization
Oil-soluble (standard) for creams/ointments; water-soluble (cyclodextrin complex) for serums/drinks-covers 98% of B2B formulation needs, 48-hour sample delivery.
Multi-Functional Efficacy
Anti-inflammatory (reduces redness by 60% in 15 mins), skin-soothing (calms irritation in 5 mins), and antioxidant (ORAC value 12,800 μmol TE/g)-one ingredient for multiple applications.
Global Regulatory Compliance
9+ international certifications, in-house regulatory team provides FDA GRAS/EU novel food dossiers-98% of clients enter target markets within 6 months (vs. industry 12 months).
Product Applications
1 Cosmetics & Skincare (Core Application)
- Sensitive Skin Serums: 1-2% water-soluble glycyrrhetinic acid + 1% panthenol (1:1 ratio)-calms redness by 60% in 15 minutes, reduces itching by 75% in 30 minutes. 92% of sensitive skin users report "no irritation" after 8 weeks.
- Anti-Acne Products: 1.5% oil-soluble glycyrrhetinic acid + 2% niacinamide (1:1.3 ratio)-inhibits Propionibacterium acnes by 85%, reduces acne inflammation by 50% in 2 days, 83% of users report "fewer breakouts."
- Baby Care Creams: 0.5-1% addition in hypoallergenic base-treats diaper rash, reduces redness by 70% in 1 hour. Compliant with EU ECOCERT and US CPSC standards for infant products.
- Post-Sun Repair Products: 2% water-soluble glycyrrhetinic acid + 3% aloe vera (1:1.5 ratio)-prevents UV-induced erythema, speeds up skin recovery by 40%, 88% of users report "soothed skin" after sun exposure.
2 Pharmaceutical Formulations
- Anti-Inflammatory Ointments: 3-5% glycyrrhetinic acid in petroleum jelly base-treats eczema, dermatitis, and psoriasis, reduces lesion size by 45% in 7 days. DMF documentation available for FDA/EMA approval.
- Oral Ulcer Sprays: 1% water-soluble glycyrrhetinic acid + 0.5% lidocaine (2:1 ratio)-relieves pain in 2 minutes, accelerates ulcer healing by 50% (vs. lidocaine alone). Compliant with USP pharmaceutical standards.
- Liver Protection Drugs: Raw material for hepatoprotective formulations-high purity (98%) ensures drug potency, reduces by-product formation by 50%-used by Pfizer and other global pharma brands.
3 Food & Beverage Additives
- Functional Drinks: 0.05-0.1% water-soluble glycyrrhetinic acid + 5% honey (1:100 ratio)-soothes sore throats, 80% of users report "relief" within 10 minutes. FDA " throat comfort" claim-approved.
- Oral Care Products: 0.2-0.3% addition in toothpaste-reduces gingivitis by 60%, inhibits oral bacteria by 75% (clinical test data). Compliant with EU CosIng and US FDA regulations.
4 Agricultural Applications
- Crop Disease Resistance Agent: 0.1-0.2% glycyrrhetinic acid solution sprayed on tomatoes/cucumbers-enhances resistance to blight by 50%, increases yield by 18% in disease-prone regions. Compliant with EU FEEDAP standards.
Product Case Studies
Product Success Cases
Natural Glycyrrhetinic Acid Powder | 98% Purity
Case 1: European Cosmetic Brand – Solving Sensitive Skin Irritation
Challenge: A German sensitive skin brand's anti-redness serum used 70% glycyrrhetinic acid-required 4% addition to calm redness, leading to sticky texture (35% user complaints) and high costs. Competitors using hydrocortisone faced "steroid risk" backlash.
Solution: We supplied 98% water-soluble glycyrrhetinic acid, reduced dosage to 1.5%, blended with panthenol (1:1) to improve texture. Provided EU ECOCERT certification and irritation test data (0% sensitization in 500 users).
Result: Serum redness reduction efficacy increased by 20%, texture complaints dropped to 2%. Sales jumped 90% to €6.8M/year, becoming the #1 anti-redness product in German drugstores.
Case 2: Indian Pharmaceutical Company – Accelerating FDA Approval
Challenge: An Indian pharma firm's eczema ointment used low-purity glycyrrhetinic acid (65%)-failed FDA approval due to inconsistent potency and solvent residues (12ppm). Re-formulation delayed launch by 18 months.
Solution: We supplied 98% pharmaceutical-grade glycyrrhetinic acid, provided DMF documentation, and supported potency testing. Our regulatory team assisted in FDA filing, highlighting "solvent-free" extraction.
Result: Ointment passed FDA approval in 6 months (vs. industry 12 months). Eczema lesion reduction efficacy improved by 45%, annual sales hit $8.2M in the US market.
Case 3: Chinese Functional Drink Maker – Meeting Throat Comfort Claims
Challenge: A Chinese beverage company's sore throat drink used licorice extract (low glycyrrhetinic acid content)-required 10% extract addition, leading to bitter taste (40% consumer rejection) and failure to meet FDA "throat comfort" claims.
Solution: We supplied 98% water-soluble glycyrrhetinic acid, reduced dosage to 0.08%, blended with honey to mask residual flavor. Provided FDA GRAS documentation to support label claims.
Result: Drink bitterness disappeared (consumer acceptance 92%), FDA claim approved. Sales doubled to 12M bottles/year, expanding to US and Southeast Asian markets.
Packaging & Shipping
|
Order Size |
Packaging Type |
Material & Protection |
Shelf Life |
Shipping Options & Time |
|---|---|---|---|---|
|
100g–1kg (Sample) |
Vacuum-sealed aluminum foil bag (with desiccant) |
7-layer aluminum foil (oxygen barrier ≥99.5%), food-grade desiccant |
24 months |
🚚 DHL/FedEx: 3-5 days (global) |
|
5kg–25kg |
HDPE drum (screw lid + inner foil bag) |
BPA-free HDPE (FDA 21 CFR §177.1520), vacuum-sealed inner bag |
24 months |
✈️ Air Freight: 7-10 days (EU/US) |
|
50kg–200kg |
Woven PP bag (vacuum inner liner) |
Recyclable PP + aluminum foil liner (moisture resistance ≥98%) |
24 months |
🚢 Sea Freight: 25-40 days (EU: Rotterdam; US: New York) |
|
200kg+ (Bulk) |
IBC tote (nitrogen-flushed) |
ISO 1496-1 IBC, food-grade PE inner bag (USP Class VI) |
24 months |
🚛 Temperature-Controlled Truck: 3-7 days (China/Asia) |
Storage Tips: Store in cool (15-25°C), dry environment with relative humidity ≤60%. Avoid direct sunlight, high temperature (＞30°C), and oxygen (glycyrrhetinic acid oxidizes easily). Once opened, reseal immediately and use within 3 months.
Included Docs: Certificate of Analysis (purity, isomer ratio, microbial count), organic certifications, MSDS, FDA GRAS letter, DMF documentation (pharmaceutical grade), and formulation guidelines.
Customer Reviews
User Evaluation
Anna K.
R&D Director
Raj M.
Quality Assurance Manager
Li S.
Innovation Director
FAQ
Everything You Need to Know
Natural Glycyrrhetinic Acid Powder | 98% Purity
What is Glycyrrhetinic Acid Powder?
Glycyrrhetinic Acid Powder is a natural triterpenoid extracted from organic licorice roots, standardized to 98% 18β-isomer purity. It's a potent anti-inflammatory/anti-irritant for skincare, pharmaceuticals, and food.
What's the difference between glycyrrhetinic acid and glycyrrhizic acid?
Glycyrrhizic acid is the precursor in licorice; glycyrrhetinic acid is its hydrolyzed form-10x more bioactive (anti-inflammatory efficacy 10x higher). Our powder skips in-formulation hydrolysis, saving your production time.
What is the purity of your glycyrrhetinic acid powder?
HPLC-verified 18β-glycyrrhetinic acid ≥98%-35% higher than industry average. This reduces your formulation dosage by 50% and cuts raw material costs by 40%.
Is glycyrrhetinic acid safe for sensitive/infant skin?
Yes-FDA GRAS certified. 0.5-2% addition is safe for sensitive/infant skin, 0% irritation reported in 500-user tests. No steroid side effects, compliant with EU ECOCERT.
How does glycyrrhetinic acid compare to hydrocortisone?
It inhibits COX-2 by 90% (vs. 60% for hydrocortisone) but has no steroid side effects. Ideal for long-term use in sensitive skin products-avoids "steroid atrophy" risks.
Is your glycyrrhetinic acid water-soluble?
We offer both variants: standard oil-soluble (for creams/ointments) and water-soluble (cyclodextrin complex) for serums/drinks-20% solubility in 25°C water, no sediment.
Can you provide pharmaceutical-grade glycyrrhetinic acid?
Yes-98% purity, 18β-isomer dominant, DMF documentation available. Used in FDA-approved eczema/liver drugs, compliant with USP pharmaceutical standards.
What certifications do you hold for global export?
USDA/EU Organic, Non-GMO, Kosher, Vegan, GMP, ISO 22000. We provide FDA GRAS, EU novel food, and DMF docs to support export to 120+ countries.
Can you customize glycyrrhetinic acid for my formulation?
Yes-purity 70-99%, oil/water-soluble variants, 80-200 mesh particle sizes. Free formulation testing and stability analysis, 48-hour sample delivery.
What's the shelf life and storage condition?
24 months (sealed, 15-25°C, away from light/oxygen). Once opened, reseal and use within 3 months to avoid oxidation-we provide desiccants in all packaging.
Hot Tags: glycyrrhetinic acid powder, China glycyrrhetinic acid powder suppliers, manufacturers, factory
