1 Semi-synthetic method
The currently developed semi-synthetic process uses p-cresol as raw material to obtain methyldimethoxybenzaldehyde through bromination, etherification and oxidation, and then condenses with solanesol extracted from tobacco or potato leaves to obtain coenzyme Q10. The key to this method is how to attach the side chain to the parent ring.
2 Total synthesis
The total synthesis method developed by Eem and Kanan in 1988 to produce coenzyme Q10 is the only successful total synthesis method at present. However, due to the difficulty in synthesizing linear unsaturated side chains and harsh synthesis conditions, there is still a certain distance from industrialization.
3 Fermentation method
In 1977, the production of coenzyme Q1o by microbial fermentation was realized. This production process is considered to be the most promising synthesis process. In recent years, microbial fermentation has become a hotspot developed at home and abroad. Rhodobacter erythrobacter, Denitrifying Trichobacterium denitrificans, Methanococcus and so on are the main strains for the production of coenzyme Q10.
4 Plant cell culture method
Plant cell culture technology is a technology in which a certain part of the plant body is aseptically treated, placed on an artificial medium to make the cells proliferate, and then cultured as needed. Various parts of the plant, such as roots, stems, leaves, flowers, fruits, anthers and pollen, can be used as explants to initiate cell culture, and the formed dedifferentiated cell mass is called callus, and the callus is transferred to Cultivation in liquid medium is called suspension culture.
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