Products Description
Cooling Agent WS-12 powder is a potent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM). It robustly activated TRPM8 in low micromolar concentrations (EC50 12+/-5 microM) thereby displaying a higher potency and efficacy compared to menthol (EC50 196+/-22 microM). The selectivity profile of WS-12, its several-fold higher potency and around two-fold increase in efficacy compared to menthol warrants its potential utility for therapy in chronic neuropathic pain states and as a diagnostic probe in prostate cancer.
It is a menthol derivative. But unlike menthol, it is virtually nonvolatile, odorless and tasteless. It offers one of the strongest initial cooling impacts and a significantly longer lasting effect comparing with such conventional coolants such as WS-3, WS-5, and WS-23. It has potential for use in mint flavors in oral care applications as well as confectionary and chewing gum depending on dosage levels. In addition it can be used at low levels to impart freshness into berry, citrus and other fruit flavors in a variety of applications. WS-12 has been found to cool primarily at the front of the tongue.
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Product Name |
Cooling Agent WS-12 |
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Specification |
≥99% |
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CAS No. |
68489-09-8 |
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Appearance |
White Crystal Powder |
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MF |
C18H27NO2 |
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Odor |
Mild cooling, slight menthol odor (almost odorless) |
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Usage |
Cooling Agent ws27 is one of the best additives for daily use products, especially in cosmetics and food. |
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Certification |
HACCP, ISO, QS, Halal, Kosher,FDA,COSMOS,IFS,BRC |
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Quality |
Non-GMO, Non-irradiation, Allergen Free, BSE/TSE Free |
basic analysis
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Analysis |
Description |
Results |
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Color and appearance |
White Solid |
Pass |
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Odor |
Almost no smell,strong menthol cooling |
Pass |
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Melting Point |
177°C~181℃ |
178.4℃ |
advantages
1.Continuous and long lasting cooling and refreshing effect, having no hot, harsh and stinging sensation of Menthol and/or Peppermint.
2. Heat-Resistance: Heating under 200oC will not reduce the cooling effect, suitable to use on baking and other high temperature heating process.
3. Its cooling intensity can maintain 15-30 minutes, enriching the refreshing of product and having no
burning pain, stabbing and numbness, it's cooler than traditional Menthol product.
4. Low dosage: 30-100 mg/kg dosage will give good cooling effect.
5. Excellent compatibility with other flavors, it can enhance the effect of the flavors. It also can be combined using with other cooling agents.
applications
1. Daily use products: Toothpaste, oral products, Air Freshener, skin cream, shaving cream, shampoo, sunscreen, shower cream.
2. Foods: Confectionery products, chocolate, dairy produce, beer, distilled spirit, beverage, Chewing Gum.
3. Medicines: Linctus, diminish inflammation ointment, dyspepsia, antipruritic, liniment, oral cavity acesodyne, heatstroke pill.
4. Other products: Cigarette, filter tip, tobacco, it also can be used in insectifuge.
Also can make different cooling and freshing agent products to suit variety new market concept.
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The difference of cooling agent |
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Product Name/Items |
Effect |
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With mint aroma, it can burst in the month, strong impact on the month. |
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It occurs slowly coolifeeling in the month, at the back of mouth and tongue. |
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WS-12 |
With Peppermint aroma, in the aral cavity explosive force is weak, enters the throat place to highlight the cooling feeling, the advantage is the duration is longer. |
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It has Peppermint aroma and highest cool flavor activity, acting on the entire oral mucosa, throat and nose. |
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The Duration |
WS-23 about 10-15 min WS-3 about 20 min WS-12 about 25-30 min WS-5 about 20-25 min |
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The cooling effect |
WS-5>WS-12>WS-3>WS-23 |
packaging and delivery
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Packaging Details |
10g/Bag,1Kg/bag/25kg/Drum,According to your requirements |
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Port |
China main port |
attribute-list
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Supply Ability |
200000 Kilogram/Kilograms per Month |
lead time
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Quantity (kilograms) |
1-500 |
＞500 |
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Lead time (days) |
5 |
To be negotiated |
OEM
We provide various dosage forms and neutral packaging including mixed powders, granules, soft capsules, hard capsules, tablets, soft candies, etc. to meet the different needs of customers. Green Spring has been committed to supplying customers with natural, safe and organic plant extracts. All the products we supply, carry out the highest standards in the international industry, complying with EU EC396, EU 2023/915 standards and the highest solvent residue standards.
❈ Certificate of Analysis
❈ Technical Data Sheets (TDS)
❈ MSDS
❈ Allergen fact sheets & statements
❈ BSE/TSE statements
❈ GMO free statements
❈ Process flow charts
❈ Method of Analysis
❈ Non-Aflatoxins contamination certificate
❈ PAHs free declaration
❈ CITES regulatory compliance
❈ Physical test
❈ Herbal active ingredients test
❈ Pesticides residue test
❈ Heavy metals test
❈ Solvents residue test
❈ Microbiological test
❈ Conventional indicators analysis
❈ Nutrition labels testing
❈ Plasticizer GC-MS
❈ Polycyclic aromatic hydrocarbons testing GC-MS
Why Choose Us
1.Focused on the development of plant active ingredients for more than 22 years and has a number of national invention patents.
2. International certification system: ISO9001, ISO22000, IP (non GMO), Jewish, halal, organic and other certification.
3. Professional and experienced r&d team: professors from famous universities and experts with decades of working experience in this industry.
4. Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.
Why Choose Us
More Than 23 Years Botanical Extract Supplier
Deliver to your hand
If you have no experience of importing products to your company, don't worry, we can help you do your local customs clearance for you. So the goods will be delivered to your hand directly. For example, we now do custom clearance for Europe, USA, etc
Great quality ensured
Our quality team and laboratory is your quality team,your laboratory.We are dedicated to providing clients with the highest quality nutritional ingredients to make the best possible products. This mission starts by ensuring that high standards are met at every step of the supply chain.
Most affordable price
Lower your purchase cost.The factory direct supply, and warehouse stock service,could lower your purchase cost,logistic cost, customer clearance cost,etc.Wide wide products range, we can provider you many products with small quantity per single order, which saving repeated logistic cost and custom clearance costs for you.
ship and delivery
Transit could be DHL,UPS,TNT, FEDEX, EMS. For mass orders, it will be delivered by air or sea.
Certifications
The company always adheres to the corporate mission of creating healthy life, strictly controls product quality and is certified with ISO9001 quality management system certificate, Halal and Kosher certificates. The company is continuously making innovations and developments and has being issued with high-tech enterprise certificate for many consecutive years. At the same time, it was granted a number of patent for inventions by State Intellectual property Office(SIPO).
BRC
IFS
COSMOS
ISO9001
Certificate name
HACCP
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